Lupus is a systemic autoimmune disease that occurs when your body's immune system attacks your own tissues and organs. Inflammation. Systemic Lupus Erythematosus; Defining Lupus; Symptoms of Lupus; Lupus and Quality of Life; Warning Signs of a Flare; Preventing a Flare; Tips for Working. Learn systemic lupus erythematosus (SLE) symptoms (butterfly rash), treatment options, diagnosis, prognosis, causes, and pregnancy flares. Read about diet.


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Thus triggers may systemic lupus erythematosus viruses, bacteria, allergens IgE and other hypersensitivityand can be aggravated by environmental stimulants such as ultraviolet light and certain drug reactions.

These stimuli begin a reaction that leads to destruction of other cells in the body and exposure of their DNA, histonesand other proteins, particularly parts of the cell nucleus. The body's sensitized B-lymphocyte cells will now produce antibodies systemic lupus erythematosus these nuclear-related proteins.

Systemic lupus erythematosus

These antibodies clump into antibody-protein complexes which stick to surfaces and damage blood vessels in critical areas of the body, such systemic lupus erythematosus the glomeruli of the kidney; these antibody attacks are the cause of SLE.

Researchers are now identifying the individual genes, the proteins they produce, and their role in the immune system.

Each protein is a link on the autoimmune chain, and researchers are trying to find drugs to break each of those links. T cells, which regulate B-cell responses and infiltrate target tissues, have defects in signaling, adhesion, co-stimulation, gene transcription, and alternative splicing.

Necrosis is increased in T lymphocytes. These cells normally engulf B cells that have undergone apoptosis after somatic hypermutation. Also, uningested apoptotic nuclei can systemic lupus erythematosus found outside of TBMs.

Lupus - Symptoms and causes - Mayo Clinic

This material may present a threat to the tolerization of B cells and T cells. Dendritic cells systemic lupus erythematosus the germinal center may endocytose such antigenic material and present it to T cells, activating them.

Also, apoptotic chromatin and nuclei may attach to the surfaces of follicular dendritic cells and make this material available for activating other B cells that may have randomly acquired self-specificity through somatic hypermutation.

This includes systemic lupus erythematosus phagocytic activity and scant serum components in addition to increased apoptosis.


SLE is associated with defects in apoptotic clearance, and the damaging effects caused by apoptotic debris. When apoptotic material is not removed correctly by phagocytes, they are captured instead by antigen-presenting cells, which leads to development of antinuclear antibodies.

Most of the monocytes and tingible body macrophages TBMswhich are found in the germinal centres of lymph nodeseven show a definitely systemic lupus erythematosus morphology; they are smaller or scarce and die earlier.

Systemic lupus erythematosus – Knowledge for medical students and physicians

Serum components like complement factors, CRPand some systemic lupus erythematosus are, furthermore, decisively important for an efficiently operating phagocytosis.

It can also cause inflammation of the blood vessels vasculitis. Having lupus increases your chances of developing an inflammation of the chest cavity lining pleurisywhich can make breathing painful. Bleeding into lungs and pneumonia also are possible.

Systemic lupus erythematosus: MedlinePlus Medical Encyclopedia

Lupus can cause inflammation of your heart muscle, your arteries or heart membrane pericarditis. The risk of cardiovascular disease and heart attacks increases greatly as well. Other types of complications Having lupus also increases your risk of: The presentation of the disease is variable and may range from mild localized symptoms to life-threatening systemic disease.

Typical findings include fever and fatigue, a malar rash facial "butterfly rash"myalgia, and arthritis. SLE is a chronic disease systemic lupus erythematosus can have phases of worsening symptoms that alternate with periods of mild symptoms.